We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.

Two developed milder encephalopathy one had no CNS depression at all. Three patients received prophylaxis with MB at a dose of 4 × 50 mg day –1 i.v. Four patients did not receive MB and all recovered only after 48 h. Four recovered fully within 24 h, two recovered partially after 24 h and completely after 48 h while two recovered only after 72 h. Eight were treated with MB at a dose of 6 × 50 mg day –1 intravenously (i.v.). Twelve patients developed central nervous system (CNS) depression, defined as National Cancer Institute Common Toxicity Criteria (NCI-CTC) neurocortical toxicity grade 2 or higher. Between 19, 52 patients (age 16–77 years) with solid tumours were treated with ifosfamide in dosages ranging from 3 to 5 g m –2 q3w when given in combination schedules and up to 12 g m –2 q4w when given as a single agent. The purpose of this study was to evaluate the neuroprotective effect of MB in these patients and to review the literature. Methylene blue (MB) may be used in the treatment of this encephalopathy. Ten to 15% of patients treated with ifosfamide develop an encephalopathy. All non-essential skin and eye contact should be avoided.Ifosfamide is an alkylating agent used in the treatment of a variety of solid tumours. Methylene Blue should not be ingested in larger quantities as it may lead to side-effects such as Hypertension, Dizziness, Headache, Fever, skin staining, Vomiting, abdominal pain, bladder irritation, urine discoloration, anemia.

Nerve Fiber: Used in staining of nerve fiberĪquaculture: Use to prevent and treat whitespot in various fish species

Staining: Used in endoscopic polypectomy to stain tissue which tells how many more tissues needs to be removedīone Cement: In orthopedic operations, it is used to distinguish between native bone and cement With Light: When combined with light, it is used to treat Hepatitis CĬuring Cyanide Poisoning: In large doses, it is also used as an antidote to potassium cyanide poisoning (tested method) Uses include:Ĭolourant: Staining of products and as a marker dye Methylene Blue 1 % solution has many uses majorly in medical purpose and aquaculture for treatmenrt of whitespot.

Methylene blue antidote